We are a provider of various services in the field of microbiology and have the corresponding infrastructure, such as S1/S2 laboratories.
Of course, we offer various (also accredited) services in the field of classical microbiology. This is based on the cultivation of bacteria and subsequent analysis (e.g. via microscopy, biochemical methods, PCR).
In addition to this traditional approach (as is often required), we also offer culture-independent methods. These include DNA/RNA sequencing of microorganisms using Next Generation Sequencing.
Do you need microorganisms as control material or for immunization? We offer safe deactivation of bacteria or viruses.
Microbiological tests
Method: Cultivation and analysis by our accredited test laboratory
Our team of 15 employees tests around 45,000 samples per year for product composition and/or microbiological safety, among other things.
The test laboratory is accredited in accordance with DIN EN ISO 17025.
DNA/RNA sequencing of microorgasms
Method: Next Generation Sequencing
Next-generation sequencing (NGS) is a new technology in the sequencing of DNA and RNA samples. In contrast to previously known sequencing methods, several hundred million fragments can be analyzed simultaneously in one sample.
At the fzmb we use various NGS technologies for short and long reads to clarify different application-related questions.
Microorganisms as control material
Method: Thermal or UV inactivation of bacteria and viruses
The use of inactivated microorganisms as control material or for immunization for antibody production can minimize the risk of infection and contamination. For this purpose, the corresponding microorganisms are inactivated by thermal or UV treatment.
We offer inactivated microorganisms as whole cell preparations (e.g. inactivated bacteria such as Legionella or Streptococcus) as standardized, independent quality controls for the evaluation of molecular tests. We can also carry out customized inactivation, e.g. of bacteria, according to your specifications. You determine the desired concentrations, buffers and additives.
Details UV and thermal inactivation
UV inactivation of bacteria and viruses
UV-inactivated bacteria and viruses are particularly well suited as microbiological control material for scientific or medical purposes. The high-energy UV light damages the DNA, causing it to be inactivated. However, the macromolecular outer surface remains intact. UV-inactivated bacteria are therefore extremely useful for the production of antibodies against surface antigens.
If inactivated bacteria are used as reference material to vital bacteria, comparable results are obtained. UV-inactivated microorganisms are also ideal for evaluating molecular tests as standardized, independent quality controls.
Thermal inactivation of bacteria and viruses
Unlike UV irradiation, our thermal process can also be used to inactivate large quantities of microorganisms in a short period of time. The specific conditions for inactivation depend on the type of organism.
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